Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
66711 | Journal of Molecular Catalysis A: Chemical | 2010 | 5 Pages |
Benzylamine (BA) is a commonly employed additive for the hydrogenation of α,β-unsaturated acids over the cinchonidine-modified palladium catalyst, but the BA addition effects largely depend on the reaction solvent. In toluene, BA is not required to obtain the high enantioselectivity. Quicker desorption of the product due to weaker acidity in toluene than in a commonly used wet dioxane reasonably explains both the kinetic properties and the product selectivities.
Graphical abstractEnantioselective hydrogenation of unsaturated acids over the cinchonidine-modified Pd/C does not require amine addition in toluene due to weaker acidity of the product to cause the smooth desorption.Figure optionsDownload full-size imageDownload high-quality image (70 K)Download as PowerPoint slide