Supercritical fluid extraction and convergence chromatographic determination of parthenolide in Tanacetum parthenium L.: Experimental design, modeling and optimization

- Optimization of three operating conditions (P, T, %EtOH) using Box-Behnken design and response surface methodology.
- The effect of the vegetation period on the accumulation of parthenolide in different parts of the plant was analyzed.
- Convergence chromatographic method was developed and validated to quantify the parthenolide content.