Development of sericin/alginate beads of ketoprofen using experimental design: Formulation and in vitro dissolution evaluation

This manuscript evaluates the development of sericin/alginate particles loaded with ketoprofen. By means of statistical design, the particles were obtained and characterized by the incorporation efficiency, in vitro dissolution, morphology, size distributions, functional groups, thermal stability, and cristallinity. The best results were obtained for the lower amount of alginate and larger amount of ketoprofen initially added.47