Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6678148 | Powder Technology | 2013 | 16 Pages |
Abstract
After wet granulation, spray-dried monohydrate lactose along with HPMC formed irregular spherical structure with homogeneous particle size while un-granulated lactose facilitated the flow and mix of powders which eventually achieved satisfied tablet evaluation results and much better outcome content uniformity. Also wet granulation stabled excipients and API and altered the in vitro dissolution profile with steady gradual release pattern.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Wan Huang, Yanan Shi, Chenhui Wang, Kongtong Yu, Fengying Sun, Youxin Li,