Pd0- and PdII-catalyzed oxaheterocyclization of substrates having both an allylic leaving group and a hydroxylated tether

This review surveys the different asymmetric and non-asymmetric Pd-catalyzed heterocyclizations of allylic alcohols, esters, ethers, carbonates, amines or silanes and vinyl epoxides, which bear a hydroxylated tether. Lactones or carbonates have been obtained from reactions carried out under carbon oxide or carbon dioxide atmosphere, respectively. The dichotomy between the mechanisms of the Pd0 and PdII processes is emphasized.

Graphical abstractA review on the palladium-catalyzed intramolecular reactions leading to oxygenated heterocycles, from substrates having both an allylic leaving group and a hydroxylated tether is presented.Figure optionsDownload full-size imageDownload high-quality image (62 K)Download as PowerPoint slide