Preparation of stable colloidal suspensions of superdisintegrants via wet stirred media milling

- Colloidal suspensions of superdisintegrants were prepared via wet media mill.
- The superdisintegrants used were crospovidone (CP) and sodium starch glycolate (SSG).
- Stabilizers used were hydroxypropyl cellulose (HPC) and sodium dodecyl sulfate (SDS).
- Extensive breakage of the superdisintegrant particles occurred during milling.
- SSG suspensions were stable w/o HPC-SDS, whereas CP suspensions required HPC-SDS.