Fast, efficient and chemoselective method for thioacetalization and transthioacetalization using catalytic amount of P2O5/Al2O3 under microwave irradiation

In this work, we have reported a mild, fast and efficient method for the preparation of 1,3-dithiolanes using catalytic amount of P2O5/Al2O3 under solvent-free conditions (MW). A wide variety of aldehydes and ketones can be easily protected to their corresponding 1,3-dithiolanes using 1,2-ethanedithiol in the presence of catalytic amount of P2O5/Al2O3 under microwave irradiation. Using this method, transthioacetalization of acetals and acylals into their corresponding 1,3-dithiolanes was also carried out in good yields and short reaction times.

Graphical abstractA wide variety of aldehydes and ketones can be easily protected to their corresponding 1,3-dithiolanes using 1,2-ethanedithiol in the presence of catalytic amount of P2O5/Al2O3 under microwave irradiation. Using this method, transthioacetalization of acetals and acylals into their corresponding 1,3-dithiolanes was also carried out in good yields.Figure optionsDownload full-size imageDownload as PowerPoint slide