Acid catalysis of different supported heteropoly acids for a one-pot synthesis of β-acetamido ketones

The production of β-acetamido ketones from aldehydes, ketones and acetyl chloride in acetonitrile over supported heteropoly acids has been examined. This study reports the use of heteropoly acids (HPAs) supported on metal oxides (SiO2, Al2O3, K 10 and KSF montmorillonite) and activated carbon as efficient and reusable catalysts, and their comparison with other catalysts in Dakin–West reaction. Dodecatungstophosphoric acid supported on KSF and γ-Al2O3 shows the best results and reusability.

Graphical abstractEfficacies of different supported heteropoly acids are investigated for the synthesis of β-acetamido ketones.Various heteropoly acids, catalyst concentration, and heteropoly acids loading on different supports are investigated. Reusability of all supported catalyst is examined. This method consistently has the advantages of excellent yields, short reaction times, and mild reaction conditions. The catalysts are inexpensive, reusable, and ecofriendly solid acids.Figure optionsDownload full-size imageDownload as PowerPoint slide