Comparative study of entropy and information change in closed and open thermodynamic systems

•The information and entropy change of the system are discussed in the context of RNA synthesis.•During synthesis reactions in a closed thermodynamic system, its information content increases while its entropy decreases.•In degradation reactions information decreases while entropy increases.•In open thermodynamic systems performing synthesis reactions both entropy and information content increase.•In open systems performing decomposition processes both entropy and information content decrease.

In this paper we discuss the entropy and information aspects of closed and open systems. The information and entropy change of the system are discussed in the context of RNA synthesis.