DSC study and phase diagrams calculation of binary systems of paracetamol

The study reports a DSC investigation of solid–liquid equilibria in three binary mixtures of paracetamol, namely with caffeine, ascorbic acid and citric acid. All these systems reveal simple eutectic behavior and eutectic temperatures and temperatures of liquidus were determined. Further, assessed eutectic and liquidus temperatures together with data for pure components were used for evaluation of parameters of the Redlich–Kister equation for the excess Gibbs energy of binary melts. Finally, binary T–x phase diagrams of the above mentioned systems were calculated using the FactSage software.

► DSC study paracetamol–caffeine, paracetamol–ascorbic acid, paracetamol–citric acid systems. ► Eutectic temperatures and temperatures of liquidus determination. ► Parameters of Redlich–Kister equation optimization. ► Binary phase diagrams calculations.