| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 674223 | Thermochimica Acta | 2012 | 7 Pages |
Abstract
⺠We clarified a protein structure under osmotic pressure by wide-angle X-ray scattering. ⺠The osmotic pressure was varied by adding high-molecular weight co-solutes. ⺠Crowding by co-solutes induced a new stable and compact structure of protein. ⺠Hydration shell density of the protein was changed. ⺠In addition, the unfolding intermediate in thermal transition was stabilized by co-solutes.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Fluid Flow and Transfer Processes
Authors
Mitsuhiro Hirai, Yoshiyuki Hagiwara, Kazuki Takeuchi, Ryota Kimura, Teruaki Onai, Rika Kawai-Hirai, Noboru Tohta, Masaaki Sugiyama,