| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 675376 | Thermochimica Acta | 2008 | 6 Pages |
Abstract
The antibacterial effect of Mn(II), tetraphenyl porphyrin (TPP), ebselen–porphyrin conjugate 1 and its manganese(II) complex 2 towards Staphylococcus aureus growth was studied by stop-flow microcalorimetry. By analyzing the power–time curves, crucial parameters such as rate constant of bacterial growth (k), half inhibitory concentration (IC50), and generation time (tG) were determined. The sequence of the antibacterial activities of these compounds tested was 2 > 1 > Mn(II) > TPP, with an IC50 value of 100 μg/mL for complex 2. Manganese(II) ebselen–porphyrin conjugate 2 is proposed to benefit from synergetic effects of Mn(II) and 1.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Fluid Flow and Transfer Processes
Authors
Xiang-Jiao Xu, Zhi Xue, Zu-De Qi, An-Xin Hou, Chao-Hong Li, Yi Liu,