Silica supported perchloric acid (HClO4–SiO2): A highly efficient and reusable catalyst for the protection of hydroxyl groups using HMDS under mild and ambient conditions

Various alcohols, phenols, naphthols, and oximes were effectively converted into their corresponding trimethylsilyl ethers with hexamethyldisilazane in the presence of solid silica supported perchloric acid under very mild conditions at room temperature with short reaction time in good to excellent yields. The notable advantages of this protocol are: work up procedure is easy and the catalyst can be recovered by simple filtration and reused.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide