Aluminum tris (dodecyl sulfate) trihydrate Al(DS)3·3H2O as an efficient Lewis acid–surfactant-combined catalyst for organic reactions in water: Efficient conversion of epoxides to thiiranes and to amino alcohols at room temperature

High yielding preparation of structurally different thiiranes, β-amino alcohols and bis(β-amino) alcohols from the reaction of epoxides with thiourea and amines in the presence of catalytic amounts of aluminum tris (dodecyl sulfate) trihydrate Al(DS)3·3H2O as a Lewis acid–surfactant-combined catalyst at room temperature in water has been described. Ring opening of epoxides with amines in the presence of this catalyst proceeded with high chemo- and regioselectivity.

Graphical abstractHigh yielding preparation of structurally different thiiranes, β-amino alcohols and bis(β-amino) alcohols by the reaction of epoxides with thiourea and amines in the presence of catalytic amounts of aluminum tris (dodecyl sulfate) trihydrate Al(DS)3·3H2O as a Lewis acid–surfactant-combined catalyst at room temperature in water has been described. All the reactions proceeded smoothly and the isolation of the products was simple and not time consuming process. Ring opening of epoxides with amines in the presence of this catalyst proceeded with high chemo- and regioselectivity. Figure optionsDownload full-size imageDownload as PowerPoint slide