Direct reductive amination of aldehydes and selective reduction of α,β-unsaturated carbonyl compounds by NaBH4 in the presence of guanidine hydrochloride in water

A selective and direct access to secondary amines and a regioselective procedure for 1,2-reduction of α,β-unsaturated aldehydes and ketones with sodium borohydride activated by guanidine hydrochloride (5 mol%) in water is described.

Graphical abstractA selective and direct access to secondary amines and regioselective procedure for 1,2-reduction of α,β-unsaturated aldehydes and ketones with sodium borohydride activated by guanidine hydrochloride (5 mol%) in water is described. Figure optionsDownload full-size imageDownload as PowerPoint slide