Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
67680 | Journal of Molecular Catalysis A: Chemical | 2008 | 5 Pages |
The paper describes our preliminary studies on the use of PMHS as a functionalizable polymer and hydride source for the kinetic resolution of secondary alcohols via chiral Cu(I)-catalyzed dehydrogenative silylating process. The chiral phosphine that chelates the Cu metal center has little influence on the selectivity factor of the kinetic resolution. The use of a stereogenic silane appears to be a key requirement to reach enantiodifferentiation in such a process.
Graphical abstractPreliminary studies on the use of PMHS as a functionalizable polymer and hydride source for the kinetic resolution of secondary alcohols via Cu(I)-catalyzed dehydrogenative silylating process is reported and discussed. Figure optionsDownload full-size imageDownload as PowerPoint slide