Sulfonamide- and hydrazine-based palladium catalysts: Stable and efficient catalysts for C–C coupling reactions in aqueous medium

Syntheses of a novel family of sulfonamide-based palladium complexes and phenylhydrazine-based palladacycles are described. These catalysts are thermally stable, and not sensitive to air and moisture and some are completely soluble in water. These catalysts have shown excellent activity (good yields and high turnover numbers) and product selectivity in several arylation reactions including Suzuki, Heck, and Sonogashira reactions carried out totally under aqueous conditions.

Graphical abstractA novel family of sulfonamide-based palladium complexes and phenylhydrazine-based palladacycles from inexpensive and readily available ligands has been synthesized. These Pd catalysts were used for C–C bond forming reactions such as Suzuki, Heck, Sonogashira reactions and arylation of allyl alcohols in the aqueous medium. Figure optionsDownload full-size imageDownload as PowerPoint slide