Article ID Journal Published Year Pages File Type
67805 Journal of Molecular Catalysis A: Chemical 2007 5 Pages PDF
Abstract

The Lewis acid (MX3)-promoted oxidation of chiral (salen)Co(II) complex afforded neither the mononuclear nor dinuclear heterobimetallic chiral (salen)Co complexes, such as [(salen)Co(III)-X]⋯MX3 or [(salen)Co(III)-X]2⋯MX3, as reported in the literatures, but rather the Jacobsen's complexes, chiral (salen)Co(III)-X. The chiral (salen)Co(III)-X complexes in situ generated by the reaction of MX3 and (salen)Co(II) in molar ratio of 1:3 were shown to have identical catalytic properties in the hydrolytic kinetic resolution (HKR) reactions of racemic epoxides, in terms of activity, enantioselectivity and stability, to those of the purified (salen)Co(III)-X complex. This result strongly indicates that metallic residues of Lewis acids (e.g., metal oxide residues) remained in the reaction mixture did not display any negative influence on the catalytic efficiencies. Thus, the present in situ method for catalyst activation can be applicable for large scale process for HKR reactions of racemic epoxides.

Graphical abstractThe Lewis acid (MX3)-promoted oxidation of catalytically inactive chiral (salen)Co(II) afforded neither the mononuclear nor dinuclear heterobimetallic (salen)Co complexes as reported in the literatures, but rather selectively the Jacobsen's complexes, chiral (salen)Co(III)-X.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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