CuBr/rac-BINOL-catalyzed Sonogashira reaction of terminal alkynes with aryl halides or arylboronic acids

CuBr/rac-BINOL-catalyzed Sonogashira coupling reaction of aryl halides with terminal alkynes was conducted smoothly to afford the corresponding products with moderate to good yields. We found that the inexpensive catalytic system was also suitable for the coupling reaction of arylboronic acids with terminal alkynes.

Graphical abstractCuBr/rac-BINOL-catalyzed Sonogashira coupling reaction of aryl halides with terminal alkynes was conducted smoothly to afford the corresponding products with moderate to good yields. We found that the inexpensive catalytic system was also suitable for the coupling reaction of arylboronic acids with terminal alkynes.Figure optionsDownload full-size imageDownload as PowerPoint slide