An efficient silica-grafted poly-(l)-leucine catalyst for asymmetric epoxidation of α,β-unsaturated ketone

A new efficient covalent immobilization method for preparation of silica-grafted poly-(l)-leucine catalyst AP-PLL-Silica gel was developed. The AP-PLL-Silica gel catalyzed asymmetric epoxidation of benzalacetophenone, yielding optically active epoxy ketone in high enantioselectivity up to 97% e.e. The catalyst was easily separated and reused several times with no significant loss of activity and enantioselectivity.

Graphical abstractA new efficient covalent immobilization method for preparation of silica-grafted poly-(l)-leucine catalyst AP-PLL-Silica gel was developed. The AP-PLL-Silica gel catalyzed asymmetric epoxidation of benzalacetophenone, yielding optically active epoxy ketone in high enantioselectivity up to 97% e.e. The catalyst was easily separated and reused several times with no significant loss of activity and enantioselectivity. Figure optionsDownload full-size imageDownload as PowerPoint slide