Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies

Article ID	Journal	Published Year	Pages	File Type
6790753	European Neuropsychopharmacology	2018	26 Pages	PDF

Abstract

We also review existing evidence supporting the involvement of miRNAs in MDD and the preclinical use of RNA interference (RNAi) strategies to target genes involved in antidepressant response. Many miRNAs have been associated to MDD, some of which e.g., miR-135 targets genes involved in antidepressant actions. Likewise, SSRI-conjugated siRNA evokes faster and/or more effective antidepressant-like responses. Intranasal application of sertraline-conjugated siRNAs directed to 5-HT1A receptors and SERT evoked much faster changes of pre- and postsynaptic antidepressant markers than those produced by fluoxetine.

Keywords

DBS 5-HT MEF2 ECT mRNA shRNA mTOR PCP MDD CRF DAT FST NMDA N-methyl-d-aspartate MPFC DLPFC MK-801 TrkB TLR PRL GluN GSK3β NBQX SWA PSD95 GluA1 TRD PCPA mGluR7 SNRI EGR1 Hdac5 eEF2 PKR DHK dsRNA KLF6 ncRNA PDE4 TREK-1 Akt-mTOR i.v α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor nuclear magnetic resonance 5-HT1A receptor BDNF EPSC rACC messenger RNA RNA interference Small interfering RNA double-stranded RNA RNAi short hairpin RNA siRNA Adenosine A1 receptor Argonaute forced swim test AChE Major depression disorder Acetylcholinesterase RNA ribonucleic acid gamma-aminobutyric acid Dopamine transporter deep brain stimulation tropomyosin receptor kinase B NMR fMRI functional magnetic resonance imaging Toll-like receptor excitatory postsynaptic currents RISC Intravenous Electroconvulsive therapy dihydrokainic acid dizocilpine SERT Serotonin serotonin transporter corticotropin releasing factor eukaryotic elongation factor 2 brain derived neurotropic factor myocyte enhancer factor 2 Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)phosphodiesterase 4 slow wave activity Phencyclidine infralimbic cortex prefrontal cortex medial prefrontal cortex Rostral anterior cingulate cortex prelimbic cortex dorso-lateral prefrontal cortex Cerebrospinal fluid CSF Sleep deprivation Selective serotonin reuptake inhibitor SSRI MicroRNA MiRNA noradrenaline Mechanistic target of rapamycin Histone deacetylase 5 Vacc Para-chlorophenylalanine early growth response protein 1 postsynaptic density protein 95 AGO Ketamine GABA glycogen synthase kinase-3 beta AMPA receptor serotonin 1A receptor Metabotropic glutamate receptor 7