Novel bis(oxazole) pincer ligands for catalysis: Application in Suzuki-Miyaura cross coupling reactions under aerobic conditions

Introducing bis(oxazole) ligands to catalysis: novel bis(oxazole) ligands could be readily synthesized from isophthaloyl dichlorides and ethyl glycinate hydrochlorides or 6-aminoacetophenone hydrochloride. Their corresponding pincer palladium complexes proved to be extremely robust catalysts for Suzuki-Miyaura cross coupling reactions, allowing the synthesis of biaryls under aerobic conditions with turn over numbers of up to 790,000 and turn over frequencies of up to 49,000 h−1.

Graphical abstractIntroducing bis(oxazole) pincer ligands to catalysis: the bis(oxazole) pincer palladium complex A proved to be an extremely robust catalyst for Suzuki-Miyaura cross coupling reactions, allowing the synthesis of biaryls under aerobic conditions with high turn over numbers and rates. Figure optionsDownload full-size imageDownload as PowerPoint slide