A novel ionic liquid supported organocatalyst of pyrrolidine amide: Synthesis and catalyzed Claisen–Schmidt reaction

A novel organocatalyst of pyrrolidine amide based on room temperature ionic liquid (RTIL) has been developed to perform Claisen–Schmidt reaction with acetone or cyclic ketone and various aromatic aldehydes at room temperature under free-solvent condition. The (E)-α,β-unsaturated ketone products were obtained in good yields. The ionic liquid supported pyrrolidine amide catalyst can be readily recovered and reused successfully without any significant loss of catalytic activity.

Graphical abstractA novel organocatalyst of pyrrolidine amide based on room temperature ionic liquid (RTIL) has been developed to perform Claisen–Schmidt reaction with acetone or cyclic ketone and various aromatic aldehydes at room temperature under free-solvent condition. The (E)-α,β-unsaturated ketone products were obtained in good yields. The ionic liquid supported pyrrolidine amide catalyst can be readily recovered and reused successfully without any significant loss of catalytic activity. Figure optionsDownload full-size imageDownload as PowerPoint slide