| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6795201 | Hormones and Behavior | 2011 | 8 Pages |
Abstract
⺠Male sex and age are risk factors for dopamine cell loss in Parkinson's disease (PD). ⺠Androgens, major male sex hormone, may influence the vulnerability of dopamine cells. ⺠Symptoms of PD were modeled in GDX and gonadally intact male rats with 6-OHDA lesion. ⺠GDX decreased 6-OHDA induced motor asymmetry and oxidative stress generation. ⺠The data implicate that androgens underlie the gender bias observed in PD.
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Authors
Rebecca L. Cunningham, Teresa Macheda, Lora Talley Watts, Ethan Poteet, Meharvan Singh, James L. Roberts, Andrea Giuffrida,