Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6797300 | Journal of the American Academy of Child & Adolescent Psychiatry | 2014 | 13 Pages |
Abstract
This study suggests that epigenetic changes in ID3, GRIN1, and TPPP genes, in combination with experiences of maltreatment, may confer risk for depression in children. The study adds to a growing body of literature supporting a role for epigenetic mechanisms in the pathophysiology of stress-related psychiatric disorders. Although epigenetic changes are frequently long lasting, they are not necessarily permanent. Consequently, interventions to reverse the negative biological and behavioral sequelae associated with child maltreatment are briefly discussed.
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Authors
Natalie MD, Huiping PhD, Kevin PhD, Bao Zhu PhD, Arthur MD, PhD, Andrea PhD, Deborah MD, Heather MA, Margrat MA, Francheska PhD, Kerry BA, James J. MD, Joel MD, Joan PhD,