| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6798461 | Journal of the American Academy of Child & Adolescent Psychiatry | 2012 | 10 Pages |
Abstract
Successful treatment of mania with divalproex may be predicted by lower baseline concentrations of Glx in the LVLPFC. In addition, in remitters, the degree of symptomatic improvement is related to the change in Glu concentrations in this region, suggesting that divalproex may work via modulation of the prefrontal glutamatergic system in youth with bipolar disorder.
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Authors
Jeffrey R. M.D., Nick C. Pharm.D., Ph.D., Wen-Jang Ph.D., Jing-Huei Ph.D., Caleb M. M.D., Mi Jung Ph.D., Holly S. B.A., David C. B.S., Jeffrey A. Ph.D., Thomas J. M.S., Jayasree J. M.D., Stephen M. M.D., Melissa P. M.D., M.S.,