Article ID Journal Published Year Pages File Type
67985 Journal of Molecular Catalysis A: Chemical 2007 5 Pages PDF
Abstract

Highly efficient, one-pot, four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles was reported the condensation of various aldehydes, benzil, aliphatic or aromatic primary amines and ammonium acetate under solvent free conditions using perchloric acid adsorbed on silica gel (HClO4–SiO2) as catalyst in excellent yields. HClO4–SiO2 exhibited remarkable catalytic activity with respect to the reaction time (2–20 min), amount of catalyst. Present protocol with HClO4–SiO2 catalyst is convincingly superior to the recently reported catalytic methods.

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Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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