Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6799443 | Journal of Psychiatric Research | 2018 | 34 Pages |
Abstract
Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (nâ¯=â¯396) comparing neurocognitive functions between CHR-P subjects (nâ¯=â¯197) and healthy controls (nâ¯=â¯199) using the MCCB were identified; 4 (66.7%) studies were rated as “high quality”. Compared to healthy controls, CHR-P subjects showed impairment with large effect size in overall cognition (nâ¯=â¯128, SMDâ¯=â¯â1.00, 95%CI: â1.38, â0.63, Pâ¯<â¯0.00001; I2â¯=â¯2%), processing speed (SMDâ¯=â¯â1.21) and attention/vigilance (SMDâ¯=â¯â0.83), and with medium effect size in working memory (SMDâ¯=â¯â0.76), reasoning and problem solving (SMDâ¯=â¯â0.71), visual (SMDâ¯=â¯â0.68) and verbal learning (SMDâ¯=â¯â0.67). No significant difference between CHR-P subjects and controls was found regarding social cognition (SMDâ¯=â¯â0.33, 95%CI: â0.76, 0.10, Pâ¯=â¯0.14; I2â¯=â¯70%) with small effect size. Apart from social cognition, CHR-P subjects performed worse than healthy control in all MCCB cognitive domains, particularly in processing speed, attention/vigilance and working memory.
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Biological Psychiatry
Authors
Wei Zheng, Qing-E. Zhang, Dong-Bin Cai, Chee H. Ng, Gabor S. Ungvari, Yu-Ping Ning, Yu-Tao Xiang,