Article ID Journal Published Year Pages File Type
6799443 Journal of Psychiatric Research 2018 34 Pages PDF
Abstract
Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66.7%) studies were rated as “high quality”. Compared to healthy controls, CHR-P subjects showed impairment with large effect size in overall cognition (n = 128, SMD = −1.00, 95%CI: −1.38, −0.63, P < 0.00001; I2 = 2%), processing speed (SMD = −1.21) and attention/vigilance (SMD = −0.83), and with medium effect size in working memory (SMD = −0.76), reasoning and problem solving (SMD = −0.71), visual (SMD = −0.68) and verbal learning (SMD = −0.67). No significant difference between CHR-P subjects and controls was found regarding social cognition (SMD = −0.33, 95%CI: −0.76, 0.10, P = 0.14; I2 = 70%) with small effect size. Apart from social cognition, CHR-P subjects performed worse than healthy control in all MCCB cognitive domains, particularly in processing speed, attention/vigilance and working memory.
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Life Sciences Neuroscience Biological Psychiatry
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