Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6801214 | Journal of Psychiatric Research | 2014 | 6 Pages |
Abstract
The present findings suggest a reactive increase in antioxidant enzymes levels during depressive episodes in early stage BD with minimal prior treatment. Also, decreased lipid peroxidation (TBARS) levels were observed, associated with lithium's clinical efficacy. Overall, these results reinforce the role for altered oxidative stress in the pathophysiology of BD and the presence of antioxidant effects of lithium in the prevention of illness progression and clinical efficacy.
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Authors
Rafael T. de Sousa, Carlos A. Jr., Marcus V. Zanetti, Alana C. Costa, Leda L. Talib, Wagner F. Gattaz, Rodrigo Machado-Vieira,