Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
680299 | Bioresource Technology | 2015 | 9 Pages |
Abstract
Focusing on the task-specific properties of ionic liquids (ILs), a novel IL was designed by combining the quaternary ammonium cationic surfactant, [N1,1,1,1]+, with benign amino acid anion ([Cys]â), and was successfully employed in whole-cell-catalyzed bioreduction by Trichoderma asperellum ZJPH0810 using an ionic liquid-distilled water medium. As expected, based on better understanding about the effects of ILs' characteristics of cations and anions on T. asperellum ZJPH0810-catalyzed bioreduction and the optimization of reaction parameters, the developed tetramethylammonium cysteine ([N1,1,1,1][Cys])-containing system is more efficient for the asymmetric reduction of 3,5-bis(trifluoromethyl) acetophenone to (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol by whole-cell catalysis in contrast to that in monophasic aqueous system. Herein, a new biotechnological application for designed type of ILs is proposed due to its novel property of strengthening coenzyme regeneration during the bioreduction process. The designed IL [N1,1,1,1][Cys] was also evaluated in Candida tropicalis 104-catalyzed bioreduction to board its application, with remarkable success.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Process Chemistry and Technology
Authors
Jun Li, Pu Wang, Jin Huang, Jia Sun,