Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6803346 | Neurobiology of Aging | 2016 | 45 Pages |
Abstract
Neurogenesis plays a role in hippocampus-dependent learning and impaired neurogenesis may correlate with cognitive deficits in Alzheimer's disease. Spatial training influences the production and fate of newborn cells in hippocampus of normal animals, whereas the effects on neurogenesis in Alzheimer-like animal are not reported until now. Here, for the first time, we investigated the effect of Morris water maze training on proliferation, survival, apoptosis, migration, and differentiation of newborn cells in β-amyloid-treated Alzheimer-like rats. We found that spatial training could preserve a short-term survival of newborn cells generated before training, during the early phase, and the late phase of training. However, the training had no effect on the long-term survival of mature newborn cells generated at previously mentioned 3 different phases. We also demonstrated that spatial training promoted newborn cell differentiation preferentially to the neuron direction. These findings suggest a time-independent neurogenesis induced by spatial training, which may be indicative for the cognitive stimulation in Alzheimer's disease therapy.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Juan Zeng, Xia Jiang, Xian-Feng Hu, Rong-Hong Ma, Gao-Shang Chai, Dong-Sheng Sun, Zhi-Peng Xu, Li Li, Jian Bao, Qiong Feng, Yu Hu, Jiang Chu, Da-min Chai, Xiao-Yue Hong, Jian-Zhi Wang, Gong-Ping Liu,