| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6803905 | Neurobiology of Aging | 2015 | 8 Pages |
Abstract
The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.
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Authors
Hana Burianová, Lars Marstaller, Jeiran Choupan, Farshid Sepehrband, Maryam Ziaei, David Reutens,