Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6803940 | Neurobiology of Aging | 2015 | 8 Pages |
Abstract
The treatment of Parkinson's disease (PD) using stem cells has long been the focus of many researchers, but the ideal therapeutic strategy has not yet been developed. The consistency and high reliability of the experimental results confirmed by animal models are considered to be a critical factor in the stability of stem cell transplantation for PD. Therefore, the aim of this study was to investigate the preventive and therapeutic potential of human adipose-derived stem cells (hASC) for PD and was to identify the related factors to this therapeutic effect. The hASC were intravenously injected into the tail vein of a PD mouse model induced by 6-hydroxydopamine. Consequently, the behavioral performances were significantly improved at 3Â weeks after the injection of hASC. Additionally, dopaminergic neurons were rescued, the number of structure-modified mitochondria was decreased, and mitochondrial complex I activity was restored in the brains of the hASC-injected PD mouse model. Overall, this study underscores that intravenously transplanted hASC may have therapeutic potential for PD by recovering mitochondrial functions.
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Hee Soon Choi, Hee Jin Kim, Jin-Hwan Oh, Hyeong-Geun Park, Jeong Chan Ra, Keun-A. Chang, Yoo-Hun Suh,