| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6806808 | Neurobiology of Aging | 2013 | 4 Pages |
Abstract
Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an “unhealthy aging” phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging.
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Authors
Joanna Collerton, Deepthi Ashok, Carmen Martin-Ruiz, Angela Pyle, Gavin Hudson, Mohammad Yadegarfar, Karen Davies, Carol Jagger, Thomas von Zglinicki, Thomas B.L. Kirkwood, Patrick F. Chinnery,