Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6809056 | Neurobiology of Aging | 2012 | 13 Pages |
Abstract
Our results confirm that resting-state functional magnetic resonance imaging signals in the sensori-motor network are suppressed in amyotrophic lateral sclerosis. A similar suppression is evident in the right fronto-parietal network, possibly reflecting the patients' frontal dysfunction and right-lateralized patterns of regional atrophy. The interaction between disease and aging in the default-mode network unravels a possible mechanism of compensation between motor and extramotor systems emerging as a supplementary functional push to help motor disturbances.
Keywords
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Authors
Gioacchino Tedeschi, Francesca Trojsi, Alessandro Tessitore, Daniele Corbo, Anna Sagnelli, Antonella Paccone, Alessandro D'Ambrosio, Giovanni Piccirillo, Mario Cirillo, Sossio Cirillo, Maria Rosaria Monsurrò, Fabrizio Esposito,