Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6809264 | Neurobiology of Aging | 2012 | 9 Pages |
Abstract
Alzheimer's disease (AD) has a complex pattern of inheritance and many genes have recently been reported to contribute to the disease susceptibility. We selected 106 SNPs within 16 candidate genes and performed a multistage association study using 4 sample sets consisting of 731 AD patients and 738 control subjects to identify genetic factors for AD in Han Chinese. A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD. The C allele increased the risk of AD 1.72-fold than the G allele (odds ratio [OR] = 1.72, 95% confidence interval [CI] = 1.17-2.53, p = 0.006) and CC carriers had a 4.89-fold higher risk for AD than that of the carriers with CG and GG genotypes (odds ratio = 4.89, 95% CI = 1.85-12.91, p = 0.001). Moreover, the CC genotype was significantly associated with earlier age at onset (p = 0.001, hazard ratio [HR] = 2.09, 95% CI = 1.38-3.18). Our data suggest that the polymorphism of IDE is associated with susceptibility to Alzheimer's disease in Han Chinese.
Keywords
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Fen Wang, Chang Shu, Longfei Jia, Xiumei Zuo, Yongbiao Zhang, Aihong Zhou, Wei Qin, Haiqing Song, Cuibai Wei, Feng Zhang, Zhen Hong, Muni Tang, Duen-Mei Wang, Jianping Jia,