Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6810140 | Neurobiology of Aging | 2011 | 5 Pages |
Abstract
Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex.
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Ageing
Authors
Gitte Nykjær Nikolajsen, Morten Skovgaard Jensen, Mark J. West,