Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6810785 | Neurobiology of Aging | 2010 | 9 Pages |
Abstract
We sought to investigate whether apolipoprotein E (APOE) genotype is associated with unique profiles of cognitive functioning during early-life. School-aged children (N = 147) received standardized achievement tests, the Rey-Osterrieth Complex Figure Test (Copy Condition; RCFT-CC), assessment of hand dominance for writing, and buccal swab testing to determine their APOE genotype. Significant differences were found on the RCFT-CC, with É2-positive children performing worse on this measure relative to both É3/3 (p = 0.032) and É4-positive children (p = 0.018). Further, a higher prevalence of left-hand dominance for writing was observed among É2-positive children (29.2%) relative to É3/3 (8.9%) and É4-positive children (6.1%; p = 0.012), although this finding did not account for the observed group differences on the RCFT-CC. Findings raise the possibility that in childhood, the É2 allele may be associated with: (a) decreased functioning in certain cognitive domains; (b) factors associated with atypical hemispheric dominance. Results may be consistent with the theory of antagonistic pleiotropy, which suggests that APOE may have different protective effects at different developmental stages.
Keywords
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Cinnamon S. Bloss, Dean C. Delis, David P. Salmon, Mark W. Bondi,