| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 68109 | Journal of Molecular Catalysis A: Chemical | 2007 | 4 Pages |
The three-component synthesis of 2,4,5-trisubstituted imidazoles, a typical acid-catalyzed reaction, could be conducted successfully with good to excellent yields in a neutral ionic liquid, 1-methyl-3-heptyl-imidazolium tetrafluoroborate ([HeMIM]BF4), under solvent-free and microwave-assisted conditions. The combined merits of microwave irradiation and ionic liquid make the three-component condensation with safe operation, low pollution, rapid access to products and simple workup.
Graphical abstractThe three-component synthesis of 2,4,5-trisubstituted imidazoles, a typical acid-catalyzed reaction, could be conducted successfully with good to excellent yields in a neutral ionic liquid, 1-methyl-3-heptyl-imidazolium tetrafluoroborate ([HeMIM]BF4), under solvent-free and microwave-assisted conditions. Figure optionsDownload full-size imageDownload as PowerPoint slide
