| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6812545 | Psychiatry Research | 2016 | 16 Pages |
Abstract
Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits and repetitive behaviors with restricted interests. A previous quantitative proteomic profiling study demonstrated that microtubule-associated stable tubule only polypeptide (STOP; also known as MAP6) protein was significant reduced in the cerebral cortex from BTBR mouse model of autism compared to the C57BL/6J mice. In the present study, the result showed that the concentration of STOP/MAP6 protein was significantly reduced in the plasma of autistic subjects than that in healthy controls. Finally, a possible mechanism of STOP/MAP6 protein in the pathogenesis of autism was proposed.
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Biological Psychiatry
Authors
Hongen Wei, Shibang Sun, Yonghong Li, Shunying Yu,