Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6812935 | Psychiatry Research | 2016 | 4 Pages |
Abstract
The etiology of OCD is largely unknown, but neuroimaging and pharmacological studies suggest that glutamatergic system plays a significant role on OCD development. We genotyped one polymorphism at GRIN2B (rs1019385) by real time Polymerase Chain Reaction in a sample of Brazilian Obsessive-Compulsive patients and healthy controls, and evaluated its influence on OCD. We found the T-allele and TT genotype to be significantly associated with OCD and ordering dimension. The T-allele was also significantly associated with checking. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.
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Authors
Fabiana Barzotti Kohlrausch, Isabele Gomes Giori, Fernanda Brito Melo-Felippe, Tamiris Vieira-Fonseca, Luis Guillermo Coca Velarde, Juliana Braga de Salles Andrade, Leonardo Franklin Fontenelle,