Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6812993 | Psychiatry Research | 2016 | 14 Pages |
Abstract
A large array of studies have investigated peripheral oxytocin (OT) and vasopressin (ADH) as potential biomarkers of psychiatric disorders, with highly conflicting and heterogenous findings. We searched Web of KnowledgeSM and Scopus® for English original articles investigating OT and/or ADH levels in different biological fluids (plasma/serum, saliva, urine and cerebrospinal fluid) across several psychiatric disorders. Sixty-four studies were included. We conducted 19 preliminary meta-analyses addressing OT alterations in plasma/serum, saliva, urine and cerebrospinal fluid of 7 psychiatric disorders and ADH alterations in plasma/serum, saliva, urine and cerebrospinal fluid of 6 psychiatric disorders compared to controls. Hedge's g was used as effect size measure, together with heterogeneity analyses, test of publication biases and quality control. None of them (except serum OT in anorexia nervosa) revealed significant differences. There is no convincing evidence that peripheral ADH or OT might be reliable biomarkers in psychiatric disorders. However, the lack of significant results was associated with high methodological heterogeneity, low quality of the studies, small sample size, and scarce reliability of the methods used in previous studies, which need to be validated and standardized.
Keywords
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Biological Psychiatry
Authors
Rutigliano Grazia, Rocchetti Matteo, Paloyelis Yannis, Gilleen James, Sardella Alberto, Cappucciati Marco, Palombini Erika, Dell'Osso Liliana, Caverzasi Edgardo, Politi Pierluigi, McGuire Philip, Fusar-Poli Paolo,