Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6813274 | Psychiatry Research | 2016 | 4 Pages |
Abstract
Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.
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Authors
Lyubov Bryushkova, Clement Zai, Sheng Chen, Irene Pappa, Viara Mileva, Henning Tiemeier, Marian Bakermans-Kranenburg, James L. Kennedy, Joseph H. Beitchman,