Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6814472 | Psychiatry Research | 2015 | 4 Pages |
Abstract
This study represents the first replication of the BDNF Val66Met â 5-HTTLPR â childhood maltreatment effect on self-reported depression symptoms using a rigorous maltreatment interview. Participants included a community sample of 339 adolescents/young adults (age 12-33; 265 female). In the context of childhood neglect, among BDNF Met-carriers, s-allele carriers of 5-HTTLPR reported significantly higher depression than l/l homozygotes, whereas a differential relation of 5-HTTLPR genotype to depression was not seen among BDNF Val/Val homozygotes.
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Authors
Kate L. Harkness, John Strauss, R. Michael Bagby, Jeremy G. Stewart, Cherie Larocque, Raegan Mazurka, Arun Ravindran, Katherine E. Wynne-Edwards, Neil A. Rector, James Kennedy,