Carboxylation and hydroxylation of biphenyl by the Pd/molybdovanadophosphoric acid/dioxygen system

Concomitant introduction of COOH and OH groups to biphenyl was achieved by allowing biphenyl to react with CO and O2 using the Pd/molybdovanadophosphoric acid catalytic system. For instance, biphenyl reacted under a mixed gas of CO (0.5 atm) and O2 (0.5 atm) in the presence of catalytic amounts of Pd(OAc)2 and H5PMo10V2O40·26H2O in acetic acid to give the corresponding hydroxybiphenylcarboxylic acids. The reaction was found to proceed through the formation of biphenylcarboxylic acid followed by hydroxylation of the resulting carboxylic acid.

Graphical abstractConcomitant introduction of COOH and OH groups to biphenyl was achieved by allowing biphenyl to react with CO and O2 using the Pd/molybdovanadophosphoric acid catalytic system. The reaction was found to proceed through the formation of biphenylcarboxylic acid followed by hydroxylation of the resulting carboxylic acid. Figure optionsDownload full-size imageDownload as PowerPoint slide