Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6816054 | Psychiatry Research | 2012 | 6 Pages |
Abstract
The aim of this study is to evaluate biological factors associated with recent suicidal attempts in a naturalistic sample. A total of 439 patients suffering from major depression disorder (MDD), bipolar disorder (BD) and psychotic disorders (schizophrenia, schizoaffective disorder and psychosis not otherwise specified), who were consecutively assessed in the Emergency Department of an Italian Hospital (January 2008-December 2009), were included. In the whole sample, suicide attempters and non-attempters differed with regard to free triiodothyronine (FT3) and prolactin values only. A univariate general linear model indicated significant effects of sex (F1;379=9.29; P=0.002), suicidal status (F1;379=4.49; P=0.04) and the interaction between sex and suicidal status (F1;379=5.17; P=0.02) on prolactin levels. A multinomial logistic regression model indicated that suicidal attempters were 2.27 times (odds ratio (OR)=0.44; 95% confidence interval (95%CI): 0.23/0.82; P=0.01) less likely to have higher FT3 values than non-attempters; while prolactin values failed to reach statistical significance (OR=0.99; 95%CI: 0.98/1.00; P=0.051). Both prolactin and thyroid hormones may be involved in a complex compensatory mechanism to correct reduced central serotonin activity. Further studies may help in understanding how these findings can be used by clinicians in assessing suicide risk.
Keywords
GGTconfidence interval.DSM-IV TRCLIADSM-III-RfT3FT4PRLTSHhptBICMDDALT5-hydroxytryptamine5-HTchemiluminescent immunoassayASTalanine transaminaseMajor depression disordermood disorderbipolar disorderDepressiontrhemergency departmentaspartate transaminaseAttempted suicideFree thyroxineBUNDiagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text RevisionFree triiodothyronineHPAMINIMini International Neuropsychiatric Interviewodds ratioblood urea nitrogenthyrotropin-releasing hormonethyroid stimulating hormoneThyroid hormoneshypothalamic–pituitary–adrenalProlactinGamma-glutamyltransferase
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Maurizio Pompili, Sara Gibiino, Marco Innamorati, Gianluca Serafini, Antonio Del Casale, Luisa De Risio, Mario Palermo, Franco Montebovi, Sandra Campi, Vincenzo De Luca, Leo Sher, Roberto Tatarelli, Massimo Biondi, Fabrice Duval, Alessandro Serretti,