| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6817205 | Psychiatry Research: Neuroimaging | 2016 | 34 Pages |
Abstract
We show that chronic MK801 administration (and thus elevated endogenous glutamate) causes significant tissue loss in rat brain, enhances neuroinflammatory pathways and may upregulate mGluR5 expression.
Keywords
i.p.FOVmGluRIDOi.v.BPNDIODMPFCN-methyl-d-aspartateNMDATSPO3-HKGSHPBOp.i.ROICTRLTDONAC3-hydroxykynurenineVOIN-acetyl-cysteinestandard uptake valuekynurenic acidQuinolinic acidIHCImmunohistochemistryPost Injectioncomputed tomographyPositron emission tomographyKYNvolume of interestintraperitonealIntravenousmedial prefrontal cortexSUVregion of interestField of viewHippocampus%IDCaudate putamenPETtranslocator proteinPlaceboKAThigh-pressure liquid chromatographyHPLCControlcingulate cortexkynurenineglutathionMetabotropic glutamate receptor
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Lauren Kosten, Jeroen Verhaeghe, Robert Verkerk, David Thomae, Livia De Picker, Leonie wyffels, Annemie Van Eetveldt, Stefanie Dedeurwaerdere, Sigrid Stroobants, Steven Staelens,