Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6817547 | Psychoneuroendocrinology | 2018 | 10 Pages |
Abstract
This study found evidence of KP metabolism imbalance in MDD patients in addition to tryptophan reduction and mild immune activation. Relationships between CRP and KYNA with some hippocampal subfield volumes in MDD patients suggest that this inflammatory signature may be associated with reduced hippocampal subfield volumes in depression.
Keywords
HAM-DHRBACMSDCTQ3-HK3-HAACES-D5-HTDSM3-hydroxykynurenine5-hydroxytryptamine (serotonin)HPAaenzyme linked immunosorbent assay3-Hydroxyanthranilic acidELAELISACNSDiagnostic and Statistical ManualBBBblood brain barriercentral nervous systemHamilton Depression Rating Scaleearly life adversityChildhood Trauma QuestionnaireC-reactive proteinCRPCHAID
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Authors
Kelly Doolin, Kelly A. Allers, Sina Pleiner, Andre Liesener, Chloe Farrell, Leonardo Tozzi, Erik O'Hanlon, Darren Roddy, Thomas Frodl, Andrew Harkin, Veronica O'Keane,