Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6817630 | Psychoneuroendocrinology | 2018 | 31 Pages |
Abstract
The endocannabinoid (EC) system influences a wide variety of neurobiological processes including affect and emotionality as well as other neuropsychiatric functions. In this study we examined the relationship of circulating endocannabinoids [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] with affect and emotionality in 175 individuals with (nâ¯=â¯115) and without (nâ¯=â¯60) mood, anxiety, and/or personality disorders. Circulating AEA levels displayed a modest, though statistically significant, inverse relationship with a composite measure of affect regulation (βâ¯=â¯ââ¯0.264, pâ¯=â¯0.009), due to its relationship with affect intensity (βâ¯=â¯ââ¯0.225, pâ¯=â¯0.021) across all study participants. Neither AEA nor 2-AG level differed as a function of any syndromal/personality disorder and neither correlated significantly with state depression or state anxiety scores. These data suggest that circulating levels endocannabinoids may play a role in emotionality across individuals regardless of defined psychiatric disorder.
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Authors
Emil F. Coccaro, Matthew N. Hill, Lauren Robinson, Royce J. Lee,