Oxytocin biases men to be more or less tolerant of others' dislike dependent upon their relationship status

showed while oxytocin decreased negative reactions to being disliked in single men it had the opposite effect on men in a relationship, and this occurred primarily when dislike was expressed by females rather than males. In contrast, for men in a relationship oxytocin enhanced mood and affiliation tendency following being liked independent of the gender of the feedback provider. Thus, oxytocin may make single men looking for a potential partner more positive socially even towards females who dislike them, but has the opposite effect in men in a relationship who are not looking for a partner. These results provide further support for the context-dependency of oxytocin effects' on social preferences, and thereby the social salience hypothesis-based explanation of its actions.